Enantioselective Michael addition of aldehydes to nitroolefins catalyzed by pyrrolidine-HOBt |
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| Authors: | Togapur Pavan Kumar Mohammad Abdul Sattar Sthanikam Siva Prasad Kothapalli Haribabu Cirandur Suresh Reddy |
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| Affiliation: | 1. Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;2. Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India;3. Department of Chemistry, Sri Venkataswara University, Tirupati 517502, India |
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| Abstract: | The oxytriazole catalyst “pyrrolidine-HOBt” developed for asymmetric Michael addition of cyclohexanone to nitroolefins is now evaluated for the asymmetric Michael addition of aldehydes to nitroolefins under similar reaction conditions. The results of this study indicate that, the oxytriazole catalyst “pyrrolidine-HOBt” is equally effective in promoting the Michael addition of aldehydes to nitroolefins on employing benzoic acid as an additive. The desired products, γ-nitrocarbonyl compounds were obtained in good yields and high enantioselectivities. |
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| Keywords: | Corresponding author at present address: Division of Natural Products Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Tel.: +91 40 27191727 fax: +91 40 27160512. |
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