Palladium-catalyzed diastereoselective synthesis of homoaldol equivalent products |
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Authors: | Yoshikazu Horino Miki Sugata Tetsu Sugita Ataru Aimono Hitoshi Abe |
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Affiliation: | Department of Applied Chemistry, Graduate School of Science and Engineering, University of Toyama, Gofuku, Toyama 930-8555, Japan |
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Abstract: | A palladium-catalyzed reaction of easily accessible 3-(pinacolatoboryl)allyl acetates and aldehydes provides facile access to synthetically useful homoaldol equivalent products with high diastereoselectivity. The reaction presumably proceeds via allylation of aldehydes with α-acetoxy allylboronates that produced in situ by reductive elimination from allylic gem-palladium/boryl intermediates. |
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Keywords: | Allylation Homoaldol equivalent reaction Palladium catalysis Allylpalladium |
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