| CoCl_2·6H_2O or LaCl_3·7H_2O Catalyzed Biginelli Reaction. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1 H)-ones |
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| 引用本文： | 路军,白银娟,郭延红,王振军,马怀让. CoCl_2·6H_2O or LaCl_3·7H_2O Catalyzed Biginelli Reaction. One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1 H)-ones[J]. 中国化学, 2002, 20(7): 681-687. DOI: 10.1002/cjoc.20020200711 |
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| 作者姓名： | 路军 白银娟 郭延红 王振军 马怀让 |
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| 作者单位： | LU，Jun ，a BAI，Yin Juan a GUO，Yan Hong b WANG，Zhen Jun a MA，Huai Rang a aDepartment of Chemistry，Northwest University，Key Laboratory of Physico Inorganic Chemistry of Shaanxi Province，Xi′an，Shaan |
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| 基金项目： | ProjectsupportedbytheNaturalScienceFoundationofShaanxiProvince (No .2 0 0 0H0 3) |
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| 摘 要： | Ｉｎｔｒｏｄｕｃｔｉｏｎ1,4 Ｄｉｈｙｄｒｏｐｙｒｉｄｉｎｅｓｏｆｔｈｅｎｉｆｅｄｉｐｉｎｅｔｙｐｅ (ｅ .ｇ .Ｉ—ＩＩＩ)ａｒｅｔｈｅｍｏｓｔｓｔｕｄｉｅｄｃｌａｓｓｏｆｏｒｇａｎｉｃｃａｌｃｉｕｍｃｈａｎｎｅｌｍｅｄｉｃｉｎｅ ,ｗｈｉｃｈｈａｖｅｂｅｃｏｍｅａｌｍｏｓｔｉｎｄｉｓｐｅｎｓ ａｂｌｅｆｏｒｔｈｅｔｒｅａｔｍｅｎｔｏｆｃａｒｄｉｏｖａｓｃｕｌａｒｄｉｓｅａｓｅｓｓｕｃｈａｓｈｙｐｅｒｔｅｎｓｉｏｎ ,ｃａｒｄｉａｃａｒｒｈｙｔｈｍｉａｓ ,ｏｒａｎｇｉｎａ .1Ｉｎｔｈｅｐａｓｔｄｅｃａｄｅ…
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CoCl2·6H2O or LaCl3·7H2O Catalyzed Biginelli Reaction. One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones |
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| Jun Lu,Yin‐Juan Bai,Yan‐Hong Guo,Zhen‐Jun Wang,Huai‐Rang Ma. CoCl2·6H2O or LaCl3·7H2O Catalyzed Biginelli Reaction. One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones[J]. Chinese Journal of Chemistry, 2002, 20(7): 681-687. DOI: 10.1002/cjoc.20020200711 |
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| Authors: | Jun Lu Yin‐Juan Bai Yan‐Hong Guo Zhen‐Jun Wang Huai‐Rang Ma |
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| Abstract: | An efficient synthesis of 3,4‐dihydropyrimidinones from aldehyde, β‐keto ester and urea in ethanol using cobalt chloride hexahydrate or lanthanum chloride heptahydrate as a catalyst was described. Compared to the classical Biginelli reaction, this new method consistently has the advantage of good yields (56%‐99%) as well as short reaction time (4–5 h). |
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| Keywords: | Biginelli reaction dihydropyrimidine 2(1 H ) ones cobalt chloride hexahydrate lanthanum chloride heptahydrate one pot process |
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