Chloride ion-catalyzed generation of difluorocarbene for efficient preparation of gem-difluorinated cyclopropenes and cyclopropanes |
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| Authors: | Wang Fei Zhang Wei Zhu Jieming Li Huaifeng Huang Kuo-Wei Hu Jinbo |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China. |
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| Abstract: | A chloride ion-catalyzed generation of difluorocarbene from a relatively non-toxic and inexpensive precursor, Me(3)SiCF(2)Cl (1), under mild and neutral conditions leads to an efficient preparation of gem-difluorocyclopropenes and difluorocyclopropanes through 2 + 1] cycloaddition reactions with alkynes and alkenes, respectively. |
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