Cytotoxicity of liver targeted drug-loaded alginate nanoparticles |
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| Authors: | ChuangNian Zhang Wei Wang ChunHong Wang Qin Tian Wei Huang Zhi Yuan XueSi Chen |
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| Institution: | 1.Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry,Nankai University,Tianjin,China;2.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,China |
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| Abstract: | In this study, novel liver targeted doxorubicin (DOX) loaded alginate (ALG) nanoparticles were prepared by CaCl2 crosslinking method. Glycyrrhetinic acid (GA, a liver targeted molecule) modified alginate (GA-ALG) was synthesized in a
heterogeneous system, and the structure of GA-ALG and the substitution degree of GA were analyzed by 1H NMR, FT-IR and elemental analysis. The drug release profile under the simulated physiological condition and cytotoxicity
experiments of drug-loaded GA-ALG nanoparticles were carried out in vitro. Transmission electron micrographs (TEM) and dynamic light scattering (DLS) analysis showed that drug-loaded GA-ALG nanoparticles
have spherical shape structure with the mean hydrodynamic diameter around 214 ± 11 nm. The drug release was shown to last
20 days, and the MTT assay suggested that drug-loaded GA-ALG nanoparticles had a distinct killing effect on 7703 hepatocellular
carcinoma cells. |
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