An efficient asymmetric oxidation of sulfides to sulfoxides |
| |
| Authors: | Philippe Pitchen Henri B Kagan |
| |
| Institution: | Laboratoire de Synthése Asymétrique (Associé au CNRS, LA no 255) Université Paris-Sud, 91405 Orsay France |
| |
| Abstract: | The Sharpless reagent (Ti(OiPr)4 + 1 mol eq. diethyl tartrate (DET) + 2 t-BuOOH) modified by addition of one mol eq. H2O gives a new homogeneous reagent which cleanly oxidizes sulfides into sulfoxides in dichloromethane. The best results were obtained for the stoichiometry Ti/DET/H2O/t-BuOOH = 1:2:1:2. The e.e. observed ranged from 4 to 93% with the highest beeing observed in the case of methyl p-toly] sulfoxide. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
