On the preparation of methyl and ethyl (r)-(−)-3-hydroxy-valerate by depolymerization of a mixed phb/phv biopolymer |
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Authors: | Dieter Seebach Max F. Züger |
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Affiliation: | Laboratorium für Organische Chemie der Eidgenössischen Technischen Hochschule, ETH-Zentrum, Universitätstrasse 16, CH-8092 Zürich Switzerland |
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Abstract: | The microbial polyester containing 70–80% 3-hydroxy-butanoate and 20–30% 3-hydroxy-pentanoate (PHB/PHV, 2) is depolymerized to give monomeric esters of (R)-configuration. These are separated by fractional distillation. (R)-3-Hydroxy-pentanoate (4) is thus made readily available as enantiomerically pure starting mortal for synthesis. |
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