The application of the sulphide contraction to the synthesis of some simple pyrrolidine alkaloids |
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| Authors: | Rodolfo. Ghirlando Arthur.S Howard Ruth.B Katz Joseph.P Michael |
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| Affiliation: | Department of Chemistry, University of the Witwatersrand, Johannesburg 2000 South Africa |
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| Abstract: | The alkaloids (±)-hygrine, (±)-dehydrodarlinine, (±)-dehydrodarlingianine, and (±)-N-methylruspolinone have been synthesised by selective reduction of vinylogous amides formed by sulphide contraction of the salts prepared by reaction of N-methyl-2-thiopyrrolidone with the appropriate bromomethyl ketones. |
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