Regioselective synthesis of (±)-gabaculine hydrochloride |
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Authors: | G. Frater U. Müller U. Schöpfer |
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Affiliation: | Givaudan Research Company Ltd. Ueberlandstrasse 138 CH - 8600 Dübendorf Germany |
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Abstract: | 3- Cyclohexenecarboxylic acid (2) has been functionalized to the protected amino acid 5 in a novel reaction sequence, the crucial step being the acid catalysed cyclization of the γ, δ-unsaturated isocyanate 3 to the bicyclic lactam 4. 5 was converted into gabaculine hydrochloride (1 · HCl). |
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