Regioselective ring opening of unsymmetrical cyclic ethers with the A1C13-NaI-acetonitrile system: Application to hydroxylation of ent-kaurene. |
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Authors: | Manabu Node Tetsuya Kajimoto Kiyoharu Nishide Eiichi Fujita Kaoru Fuji |
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Institution: | Institute for Chemical Research, Kyoto University, Uji, Kyoto 611, Japan |
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Abstract: | Unsymmetrically substituted 5-membered cyclic ethers were effectively cleaved with the A1C13-NaI-CH3CN system at the less hindered carbon atom to afford δ-iodoalcohols. Conversion of ent-kaurene to ent-14α- and ent-12β-hydroxykaurene was achieved through the ring opening of the cyclic ether with the present system as a key step. |
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