Mechanism of stigmasterol dealkylation in insect |
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| Authors: | Yoshinori Fujimoto Miki Kimura Akihiro Takasu Fathy AM Khalifa Masuo Morisaki Nobuo Ikekawa |
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| Institution: | Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152, Japan |
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| Abstract: | Deuterated stigmasterols (10, 11 and 12) were chemically synthesized and fed to silk-worm larvae. GC-MS analysis of the metabolites, cholesterol (4) and desmosterol (6), indicates the migration of 25-hydrogen to C-24 position during stigmasterol dealkylation. 22,24(28)-Dienes(8a and 8b) were shown to be converted to 22,24-diene (5), desmosterol and cholesterol. |
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