The efficient synthesis of chiral key intermediates for monobactam antibiotics |
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Authors: | Atsushi Nishida Masakatsu Shibasaki Shiro Ikegami |
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Affiliation: | Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa 199-01, Japan |
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Abstract: | Chemical asymmetric syntheses of the key intermediates (4,6,8) for the synthesis of monobactam antibiotics (SQ 26776 (azthreonam), sulfazecin, and SQ 26180) are accomplished from (±)-4-phenylsulfonyl-2-azetidinone. |
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