Stereocontrolled construction of a spiro fused bicyclo[2.2.2]Octane ring system by the intramolecular double michael reaction |
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| Authors: | Masataka Ihara Masahiro Toyota Keiichiro Fukumoto Tetsuji Kametani |
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| Institution: | 1. Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan;2. Institute of Medicinal Chemistry, Hoshi University, Ebara, 2-4-41, Shinagawa-ku, Tokyo 142, Japan |
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| Abstract: | The lithium enolate from the cyclohexenone (8) possessing the α, β-unsaturated ester moiety caused an intramolecular double Michael reaction to produce stereoselectively the spiro fused bicyclo2.2.2]-octane (10). |
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