Synthesis of (±)-ascochlorin, (±)-ascofuranone and LL-Z1272 |
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Authors: | Kenji Mori Takafumi Fujioka |
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Institution: | Department of Agricultural Chemistry, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113, Japan |
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Abstract: | Three antibiotics with a common structural feature as prenylated phenols were synthesized: (±)-ascochlorin (5 - chloro-2,4 - dihydroxy - 6 - methyl - 3 - (2E',4/E') - 5' - (1′,2′,6′ - trimethyl - 3′-oxocyclohexyl) - 3' - methyl - 2',4' - p benzaldehyde), (±)-ascofuranone (5 - chloro - 2,4 - dihydroxy - 6 - methyl - 3 - (2'E,6'E) - 7' - (3′,3′ - dimethyl - 4′ - oxo - 2′ - oxacyclopentyl) - 3',7 -dimethyl - 2',6' - heptadienyl] benzaldehyde) and LL-Z1272α (5 - chloro - 2,4 - dihydroxy - 6 - methyl -3 - (2'E,6'E) - 3',7',11' - trimethyl - 2',6', 10' - dodecatrienyl] benzaldehyde) |
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