An efficient synthesis of optically active 4-demethoxy anthracyclinones |
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Authors: | Fatima Bennani Jean-Claude Florent Michel Koch Claude Monneret |
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Affiliation: | Dèpartement de Pharmacognosie de l''Universitè Renè Descartes, ERA au CNRS n ° 950, Facultè des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l''Observatoire, 75270 Paris Cedex 06 France |
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Abstract: | Optically active 4-demethoxy-anthracyclinones related to daunorubicin were synthesized in several steps from lactose as chiral precursor of ring A and from leucoquinizarine as precursor of rings B, C and D. |
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