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An efficient synthesis of optically active 4-demethoxy anthracyclinones
Authors:Fatima Bennani  Jean-Claude Florent  Michel Koch  Claude Monneret
Affiliation:Dèpartement de Pharmacognosie de l''Universitè Renè Descartes, ERA au CNRS n ° 950, Facultè des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l''Observatoire, 75270 Paris Cedex 06 France
Abstract:Optically active 4-demethoxy-anthracyclinones related to daunorubicin were synthesized in several steps from lactose as chiral precursor of ring A and from leucoquinizarine as precursor of rings B, C and D.
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