A new alkylamidation reactionRegiospecific condensation of carbanions on cyclo 1,3- oxoimminium salts |
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Authors: | M Dreme S Brunel P Le Perchec J Garapon B Sillion |
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Affiliation: | C.N.R.S. Laboratoire des Matériaux Organiques, B.P. 24,69390 Vernaison France;Institut Français du Pétiole (CEDI), B.P. 3,69390 Vernaison France |
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Abstract: | Cyclo 1,3-oximminium salts are found to react regiospecifically with functional carbanions. Steric effects induced at the C-2 site on salts or at the carbanionioc centers promote the condensation at the C-5 or C-6 opposite sites. A bulky substituent such as 2-mesityl group is a powerful auxiliary which not only modifies the steric environment at the reactive C-2 site but also contributes to enhance the reactivity of the cyclo oxoimminium ring. |
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