Synthese totale de steroides a cycle c aromatique |
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| Authors: | C Berrier JP Gesson JC Jacquesy A Renoux |
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| Institution: | Laboratoire de Chimie XII, E.R.A. 556 “Synthèse et Réactivité de Produits Naturels”, Faculté des Sciences 40, Avenue du Recteur Pineau 86022, Poitiers France |
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| Abstract: | The ring-C aromatic analogue 4 of 4-androstene 3,17-dione and its 11 hydroxylated (methoxylated) derivatives 20a(b) were prepared by a practical synthetic route. The key steps of the sequence are achieved in superacid: the cyclisation of diarylethane 5a to phenanthrenone 17, and the hydroxylation by hydrogen peroxide of ketone 4 to phenol 20a. |
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