Tris(pentafluorophenyl)borane: a mild and efficient catalyst for the chemoselective tritylation of alcohols |
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| Authors: | Ch Raji Reddy G Rajesh SV Balaji N Chethan |
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| Institution: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | An efficient acid-catalyzed protection of alcohols as trityl ethers is described using triphenylmethanol in the presence of tris(pentafluorophenyl)borane (3 mol %) in dichloromethane at room temperature. The chemoselectivity of this protocol is demonstrated by studying the tritylation of a primary alcohol in the presence of a secondary alcohol and also the mildness of this catalyst was studied with substrates containing acid labile protecting groups. |
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| Keywords: | Tris(pentafluorophenyl)borane Chemoselective Tritylation Alcohol Lewis acid |
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