Stereoselective total synthesis of pachastrissamine (jaspine B) |
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| Authors: | Mikko Passiniemi |
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| Affiliation: | Laboratory of Organic Chemistry, Helsinki University of Technology, PO Box 6100, FIN-02015 HUT, Finland |
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| Abstract: | A short total synthesis of the cytotoxic natural product pachastrissamine is described. The synthesis includes eight steps starting from Garner’s aldehyde and proceeds in 20% overall yield. Pd(0)-mediated intramolecular cyclisation and Ru-mediated cross-metathesis are the key reactions in this sequence. |
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| Keywords: | Natural products Enantioselective synthesis Pachastrissamine Cross metathesis Cyclization |
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