含磷脂酰胆碱的聚乳酸的诱导矿化研究

分别以甘油磷脂酰胆碱和1,4-丁二醇为引发剂开环丙交酯,制备了含磷脂酰胆碱的聚乳酸(PLA-PC)和聚乳酸(PLA),比较了两者在诱导矿化中的差异.用傅立叶红外光谱仪(FTIR)、X-射线衍射仪(XRD)和扫描电子显微镜(SEM)对PLA-PC膜表面形成的矿化物进行了表征.结果表明,形成的矿化物为羟基磷灰石(HAP),PLA-PC膜有利于成核和生长,晶体呈片状,并随矿化时间延长,HAP晶粒逐渐增大,晶片厚度也逐渐变大.

STUDY ON INDUCING MINERALIZATION OF POLYLACTIDE CONTAINING PHOSPHORYLCHOLINE

Polylactide containing phosphorylcholine(PLA-PC) and polylactide(PLA) were synthesized with lactide(LA) as monomer,glycerophosphorylcholine and 1,4-butanediol as ring-opening initiators respectively.The comparison investigation of inducing mineralization on PLA-PC and PLA films was conducted.The result demonstrated that mineralized products could form on the film of PLA-PC as well as on the film of PLA in the simulated body fluid(SBF) of pH 6.8.Moreover,formation of the mineralized products was easier on the film of PLA-PC than on the film of PLA.The reason for that is phosphorylcholines can migrate to the surfaces of polymers when PLA-PC contacts with water,and PLA-PC can combine with more Ca2+ than PLA because phosphoryl in PLA-PC can combine with Ca2+ owing to the interaction between negative charge and positive charge.Fourier-transform infrared(FTIR),X-ray diffraction(XRD) and scanning electron microscopy(SEM) were used to characterize the mineralized products formed on the surface of PLA-PC films.The results showed that the mineral crystal was hydroxylapatite(HAP) and the crystal had a laminated structure.PLA-PC films are good for nucleation and development of crystals.The crystalline grains and crystalline thickness grew with increasing mineralization time.Therefore,PLA-PC is a promising biodegradable scaffolds material for bone tissue engineering.