NMR spectroscopy of interaction of some organophosphorus insecticides with liposomes

The interaction of the organophosphorus insecticides GA-41, chlorophos [trichlorfon] and OKh-30 with liposomes from lecithin and a mixture of lecithin and cardiolipin has been studied by NMR spectroscopy on¹H and³¹P nuclei. Absence of a specific interaction of chlorophos and OKh-30 with liposomes has been shown. On interacting with model membranes, GA-41 intercalates into the region of the hydrocarbon chains of the phospholipids and at particular concentrations induces the formation of certain defects in the structure of the bilayer, which leads to the penetrability of the liposomes for Pr³⁺ ions.Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 107–111, January–February, 1988.