Characterization of charge separation in the array of Micromachined UltraSonic Electrospray (AMUSE) ion source for mass spectrometry |
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| Authors: | Thomas P Forbes R Brent Dixon David C Muddiman F Levent Degertekin Andrei G Fedorov |
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| Institution: | aG. W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA;bW. M. Keck FT-ICR Mass Spectrometry Laboratory, North Carolina State University, Raleigh, North Carolina, USA;cParker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA |
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| Abstract: | An initial investigation into the effects of charge separation in the Array of Micromachined UltraSonic Electrospray (AMUSE)
ion source is reported to gain understanding of ionization mechanisms and to improve analyte ionization efficiency and operation
stability. In RF-only mode, AMUSE ejects, on average, an equal number of slightly positive and slightly negative charged droplets
due to random charge fluctuations, providing inefficient analyte ionization. Charge separation at the nozzle orifice is achieved
by the application of an external electric field. By bringing the counter electrode close to the nozzle array, strong electric
fields can be applied at relatively low DC potentials. It has been demonstrated, through a number of electrode/electrical
potential configurations, that increasing charge separation leads to improvement in signal abundance, signal-to-noise ratio,
and signal stability. |
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