| Enzymatic Promiscuity： ＂Amano＂ Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media |
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| 作者姓名： | JIANG Ling YU Hongwei |
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| 作者单位： | Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, P. R. China |
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| 基金项目： | Supported by the Program for Zhejiang Leading Team of Science ＆ Technology Innovation, China（No.2011R50007）, the National Natural Science Foundation of China（Nos.21176215, 21176102） and the Outstanding Young Scholar Grant of Zhejiang University, China（No.R4110092）. |
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| 摘 要： | ＂Amano＂ lipase AS（lipase from Aspergillus niger）, which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.
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| 关 键 词： | 萘衍生物 脂肪酶 吡喃衍生物 催化 水介质 合成 酶法 多组分反应 |
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