Mild conditions for the synthesis of functionalized pyrrolidines via Pd-catalyzed carboamination reactions |
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Authors: | Bertrand Myra Beaudoin Leathen Matthew L Wolfe John P |
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Institution: | Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, Michigan 48109-1055, USA. |
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Abstract: | reaction: see text] The palladium-catalyzed carboamination of N-protected gamma-aminoalkenes with aryl bromides and triflates has been achieved under new, mild reaction conditions using the weak base Cs(2)CO(3) in dioxane solvent. These reactions tolerate a wide variety of functional groups, including enolizable ketones, nitro groups, methyl esters, and acetates, which are not compatible with previously described conditions. |
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