| 微波辐射下浓硫酸催化嘧啶酮的无溶剂合成 |
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| 引用本文： | 梁兵,王锡天,王进贤.微波辐射下浓硫酸催化嘧啶酮的无溶剂合成[J].化学研究与应用,2006,18(8):927-930. |
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| 作者姓名： | 梁兵 王锡天 王进贤 |
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| 作者单位： | 西北师范大学化学化工学院,甘肃,兰州,730070 |
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| 基金项目： | 国家自然科学基金;甘肃省自然科学基金;甘肃省重点实验室基金 |
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| 摘 要： | 微波辐射下,以浓硫酸为催化剂,芳香醛、尿素和乙酰乙酸乙酯为原料,无溶剂下发生B iginelli缩合反应,高产率地合成了10个3,4二-氢嘧啶-2酮-衍生物。该方法不仅反应条件温和,反应时间短,避免使用昂贵的催化剂,后处理过程简单,而且避免了使用溶剂给环境带来的污染,具有绿色合成的特点。
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| 关 键 词： | 芳香醛 尿素 乙酰乙酸乙酯 微波 3 4二-氢嘧啶-2酮-衍生物 合成 |
| 文章编号： | 1004-1656（2006）08-0927-04 |
| 收稿时间： | 2005-11-08 |
| 修稿时间： | 2006-03-16 |
Synthesis of substituted 3,4-dihydropyrimidin-2(1-H)-ones under microwave irradiation and solvent-free condition catalyzed by sulphuric acid |
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| LIANG Bing,Wang Xi-tain,WANG Jin-xian.Synthesis of substituted 3,4-dihydropyrimidin-2(1-H)-ones under microwave irradiation and solvent-free condition catalyzed by sulphuric acid[J].Chemical Research and Application,2006,18(8):927-930. |
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| Authors: | LIANG Bing Wang Xi-tain WANG Jin-xian |
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| Institution: | Northwest Normal University, College of Chemistry and Chemical Engineering, Lanzhou 730070, China |
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| Abstract: | Ten Substituted 3,4-dihydropyrimidin-2(1-H)-ones were synthesized by three-component one-pot reaction of aromatic aldehydes,ethyl acetoacetate and urea using sulphuric acid as catalyst under microwave irradiation and solvent-free conditions.Advantages of the present method are the excellent yield,operational simplicity and avoidance of the use of solvent. |
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| Keywords: | aryl aldehydes urea ethyl actoacetone microwave substituted 3 4-dihydropyrimidin-2(1-H)-ones green synthesis |
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