Chymotrypsin inhibitory triterpenoids from Silybum marianum |
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| Authors: | Ahmed Ejaz Malik Abdul Ferheen Sadia Afza Nighat Azhar-Ul-Haq Lodhi Muhammad Arif Choudhary Muhammad Iqbal |
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| Institution: | International Center for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan. |
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| Abstract: | Marianine, the new lanostane triterpene (1) and marianosides A (2) and B (3) have been isolated from the whole plant of Silybum marianum. Their structures were elucidated on the basis of extensive analysis of their one dimensional and two dimensional nuclear magnetic resonance (1D, 2D-NMR) spectral data. All inhibited chymotrypsin in a concentration-dependent manner. |
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