One-Step Three-Component Synthesis of New 2,5,6,7-Functionalized 5,8-Dihydropyrido-[2,3-<Emphasis Type="Italic">d</Emphasis>]pyrimidin-4(3<Emphasis Type="Italic">H</Emphasis>)-ones |
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| Authors: | R G Melik-Ohanjanyan T R Hovsepyan G S Karakhanyan S G Israelyan L E Nersesyan G A Panosyan |
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| Institution: | 1.Mndzhoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of Armenia,Yerevan,Armenia;2.Molecular Structure Research Center, Scientific Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of Armenia,Yerevan,Armenia |
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| Abstract: | One-step three-component cyclocondensation of 2,6-disubstituted pyrimidin-4(3H)-ones with 1,3-dicarbonyl compounds and some aromatic and heterocyclic aldehydes on heating or under microwave irradiation afforded new functionally substituted 5,8-dihydropyrido2,3-d]pyrimidin-4(3H)-ones. Conventional heating was found to be more advantageous. The effects of the 2-substituent in the initial pyrimidin-4(3H)-one and the nature of the dicarbonyl component on the product structure and yield were analyzed. |
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