Metallomicellar Complex of 1-Hexadecyl-4-aza-1-azoniabicyclo-[2.2.2]octane Bromide with Copper Dibromide for Solubilization of Nitrofurantoin |
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| Authors: | E. P. Zhil’tsova M. R. Ibatullina S. S. Lukashenko M. P. Kutyreva L. Ya. Zakharova |
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| Affiliation: | 1.Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences,Kazan, Tatarstan,Russia;2.Kazan (Volga Region) Federal University,Kazan, Tatarstan,Russia |
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| Abstract: | Associates of amphiphilic 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide–copper dibromide complex solubilize nitrofurantoin (furadonin). The solubilizing capacity of premicellar aggregates with respect to nitrofurantoin is 15 times higher than that of micelles and is considerably higher (by a factor of 5–16) than the solubilizing effect of micellar solutions of the complex, ligand, and conventional cationic surfactants with respect to Orange OT. |
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