Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-<Emphasis Type="Italic">b</Emphasis>]quinoline-4,6-diones and -2,4,6-Triones |
| |
| Authors: | T R Hovsepyan G S Karakhanyan S G Israelyan G A Panosyan |
| |
| Institution: | 1.Mnjhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of the Republic of Armenia,Yerevan,Armenia;2.Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry,National Academy of Sciences of the Republic of Armenia,Yerevan,Armenia |
| |
| Abstract: | A series of new pyrimido4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido4,5-b]quinolines which are of interest for biological screening. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
