Synthesis and Characterization of Disulfide-Schiff Base Derivatives and <Emphasis Type="Italic">in vitro</Emphasis> Investigation of Their Antibacterial Activity Against Multidrug-Resistant <Emphasis Type="Italic">Acinetobacter baumannii</Emphasis> Isolates: A New Study |
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| Authors: | S Durmus A Dalmaz E Calıskan G Dulger |
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| Institution: | 1.Department of Chemistry, Faculty of Science and Arts,Duzce University,Konuralp, Duzce,Turkey;2.Department of Chemistry, Graduate School Natural and Applied Sciences,Duzce University,Konuralp, Duzce,Turkey;3.Department of Medical Microbiology, Faculty of Medicine,Duzce University,Konuralp, Duzce,Turkey;4.Department of Medical Biology, Faculty of Medicine, Duzce University,Duzce University,Konuralp, Duzce,Turkey |
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| Abstract: | In this study two different methods without a catalyst and with a CeO2 nano catalyst were used for the synthesis of dimeric disulfide-Schiff bases. The dimeric disulfide-Schiff base derivatives were characterized by FT-IR, NMR, and MS spectra, and elemental analysis. The disulfide-Schiff bases and their derivatives 2–5c were screened for in vitro antibacterial activity against 40 multidrug-resistant strains of Acinetobacter baumannii, and their minimum inhibitory concentrations were determined. Most of products exhibited high antibacterial activity against Acinetobacter baumannii. |
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