Synthesis of <Emphasis Type="Italic">N</Emphasis>-Tosylates of 4-Methoxy-1,2,3,4-tetrahydrocarbazole and 2-(6-Methoxy-1-cycloalken-1-yl)anilines |
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| Authors: | I А Kirillova М M Zalimova R V Mulyukova Yu V Vakhitova R N Khusnitdinov R R Gataullin |
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| Institution: | 1.Bashkir State University,Ufa,Russia;2.Institute of Biochemistry and Genetics, Ufa Scientific Center,Russian Academy of Sciences,Ufa,Russia;3.Institute of Organic Chemistry,Russian Academy of Sciences,Ufa,Russia |
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| Abstract: | The reaction of N-tosylates of 2-(1-cycloalken-1-yl)anilines and 2,3,9a,9-tetrahydro-1H-carbazole with methanol in the presence of CuBr2 proceeds with high regioselectivity leading to the corresponding tosylates of 2-(6-methoxy-1-cycloalken-1-yl)anilines and 4-methoxy-1,2,3,4-tetrahydrocarbazole. The latter as well as N-mesyl-1,2,3,4-tetrahydrocarbazole showed moderate cytotoxic activity with respect to HEK293 cell line. |
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