| 双氢杨梅素与G-四链体的相互作用研究 |
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| 引用本文： | 蒋才武,李炳超,唐乾利. 双氢杨梅素与G-四链体的相互作用研究[J]. 化学学报, 2007, 65(19): 2159-2162 |
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| 作者姓名： | 蒋才武 李炳超 唐乾利 |
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| 作者单位： | 广西中医学院,南宁,530001;广西中医学院,南宁,530001;广西中医学院,南宁,530001 |
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| 摘 要： | 双氢杨梅素(DMY)是从药用植物——广西藤茶中提取出来的一种含量极高的二氢黄酮醇类化合物, 具有抗肿瘤、抗氧化、调节血糖等作用, 但其抗肿瘤机理尚不清楚. 本文利用Tm值和CD光谱对G-四链体进行了表征, 利用电子吸收光谱和竞争性结合实验研究了DMY与G-四链体的相互作用. 结果显示DMY是通过外部堆积结合到G-四链体, 并通过稳定G-四链体结构而抑制端粒酶活性, 起到抗肿瘤的作用.
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| 关 键 词： | DMY G-四链体 UV-滴定 结合模式 |
| 收稿时间： | 2007-01-12 |
| 修稿时间： | 2007-01-12 |
Interaction between Dihydromyricetin and G-quartet |
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| JIANG Cai-Wu,LI Bing-Chao,TANG Qian-Li. Interaction between Dihydromyricetin and G-quartet[J]. Acta Chimica Sinica, 2007, 65(19): 2159-2162 |
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| Authors: | JIANG Cai-Wu LI Bing-Chao TANG Qian-Li |
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| Affiliation: | (Guangxi Traditional Chinese Medical University, Nanning 530001) |
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| Abstract: | Dihydromyricetin (DMY) is a kind of 2,3-dihydroflavonol compound extracted from Ampelopsis grossedentata (Hand-Mazz) W. T. Wang, which plays a role in anti-cancer processes, anti-oxidization and blood sugar adjustment, but the mechanism of its anti-cancer role remains unclear. In this article G-quartet properties were examined through Tm values and CD spectrometry. The interaction between DMY and G-quartet was investigated through Ultra-Violet spectrometry and competitive binding method. DMY was demonstrated to bind G-quartet via exterior stacking, inhibit telomerase activity by stabilizing G-quartet and hence played anti-cancer role. |
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| Keywords: | dihydromyricetin G-quartet UV-titration binding model |
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