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Reaction of 5,5-dialkyl-2-halo-6-hydroxy-5,6-dihydro-1H-pyridine-3,4,4-tricarbonitriles with Morpholine |
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| Authors: | Eremkin A V Ershov O V Lipin K V Kayukov Ya S Nasakin O E Tafeenko V A |
| Institution: | 1.I.N. Ul’yanov Chuvash State University, Moskovskii pr. 15, Cheboksary, 428015, Russia ;2.Faculty of Chemistry, Moscow State University, Vorob’evy gory 1, Moscow, 119992, Russia ; |
| Abstract: | 5,5-Dialkyl-2-halo-6-hydroxy-5,6-dihydro-1H-pyridine-3,4,4-tricarbonitriles reacted with morpholine in aprotic solvent to give the corresponding 3,3-dialkyl-4,5-dicyano-6-halo-2-morpholino-1,2,3,4-tetrahydropyridine-4-carboxamides, while analogous reaction in amphiprotic solvent resulted in the formation of 8,8-dialkyl-3-halo-6-oxo-2,7-diazabicyclo3.2.1]oct-3-ene-4,5-dicarbonitriles. |
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