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Expression patterns of Neil3 during embryonic brain development and neoplasia |
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| Authors: | Gunn A Hildrestrand Christine G Neurauter Dzung B Diep Cesilie G Castellanos Stefan Krauss Magnar Bj?r?s and Luisa Luna |
| Institution: | (1) Centre for Molecular Biology and Neuroscience, Department of Molecular Biology, Institute of Medical Microbiology, Rikshospitalet, Oslo University Hospital, Oslo, Norway;(2) Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, A?s, Norway;(3) Department of Production Animal Clinical Science, The Norwegian School of Veterinary Science, Oslo, Norway |
| Abstract: | BackgroundThe base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions. NEIL3 is one of 11 mammalian DNA glycosylases identified to date and it was discovered on the basis of sequence homology to the E. coli Fpg and Nei glycosylases. Difficulties in purifying the protein have limited its biochemical characterization and in contrast to the other glycosylases, its function remains unclear. |
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