Quinoline-3-carboxylates as potential antibacterial agents |
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| Authors: | V Krishnakumar Fazlur-Rahman Nawaz Khan Badal Kumar Mandal Sukanya Mitta Ramu Dhasamandha Vindhya Nanu Govindan |
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| Institution: | 1. Organic and Medicinal Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632014, Tamil Nadu, India
2. Environmental and Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore, 632014, Tamil Nadu, India
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| Abstract: | The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved from o-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline-3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3-carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity. |
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