Synthesis of N-[5-alkoxy-2(5H)-furanonyl] amino acid propargyl esters |
| |
Authors: | Yue-He Tan Zhao-Yang Wang Ji Qi Jin-Feng Xiong Mei-Xiang Lv |
| |
Affiliation: | 1. School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, People??s Republic of China
|
| |
Abstract: | Using K2CO3 as a base and CH3CN as solvent, different kinds of N-[5-alkoxy-2(5H)-furanonyl] amino acids were reacted with propargyl bromide via substitution reaction at 40?°C to give 16 N-[5-alkoxy-2(5H)-furanonyl] amino acid propargyl esters with the yields of 44?C85% (mostly over 74%). The structures of all newly synthesized compounds were elucidated and confirmed by FTIR, UV, 1H NMR, 13C NMR, MS, and elemental analysis. The rapid, efficient, and brief synthesis of the series propargyl esters with multiple bioactive units, will afford not only a basis for the activity test of potential drug molecules, but also an important synthetic strategy for 2(5H)-furanone derivatives with polyfunctional groups. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|