Synthesis of N-[5-alkoxy-2(5H)-furanonyl] amino acid propargyl esters

Using K₂CO₃ as a base and CH₃CN as solvent, different kinds of N-5-alkoxy-2(5H)-furanonyl] amino acids were reacted with propargyl bromide via substitution reaction at 40?°C to give 16 N-5-alkoxy-2(5H)-furanonyl] amino acid propargyl esters with the yields of 44?C85% (mostly over 74%). The structures of all newly synthesized compounds were elucidated and confirmed by FTIR, UV, ¹H NMR, ¹³C NMR, MS, and elemental analysis. The rapid, efficient, and brief synthesis of the series propargyl esters with multiple bioactive units, will afford not only a basis for the activity test of potential drug molecules, but also an important synthetic strategy for 2(5H)-furanone derivatives with polyfunctional groups.