Derivatives of orotic acid and its analogs

The lactone of 2, 6-dichloro-5-(hydroxymethyl)pyrimidine-4-carboxylic acid is synthesized, and various 2-chloro-6-amino and 2, 6-diamino derivatives are prepared from it by ammonolysis. It is shown that treatment of these compounds with alkaline reagents leads to lactone ring opening when there is a primary or secondary amino group at position 6, while the lactone ring is unaffected if there is a tertiary amino group at that position.A study is made of the action of dilute solutions of hydrochloric acid on the amino derivatives obtained by opening the lactone ring, and their reverse conversion to the corresponding 2, 6-substituted lactones of 5-(hydroxymethyl)pyrimidine-4-carboxylic acid is demonstrated.For Part III see 1].