偏最小二乘法用于药物分析

PARTIAL LEAST-SQUARES REGRESSION APPLIED TO PHARMACEUTICAL ANALYSIS

In this paper, the application of partial least-squares regression (PLS) method to multicomponent drug analysis using UV spectrophotometry has been investigated. The PLS method is comparable favourably with ordinary least squares (OLS) and multiple linear regression (MLR) methods especially when there is interaction between the components to be determined and the spectral additivity is violated. The procedure was applied to the assay of aminopyrine-phenacetin composite tablets and satisfactory recoveries were obtained.