Synthesis of amide derivatives of chlorin e6 |
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| Authors: | D. V. Belykh L. P. Karmanova L. V. Spirikhin A. V. Kuchin |
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| Affiliation: | (1) Institute of Chemistry, Komi Research Center, Ural Division, Russian Academy of Sciences, ul. Pervomaiskaya 48, Syktyvkar, 167982, Russia;(2) Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054, Bashkortostan, Russia |
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| Abstract: | A number of secondary and tertiary chlorin e 6-13-amides were synthesized in high yield by the action of primary and secondary amines on methylpheophorbide a under mild conditions. Unlike the secondary amides, tertiary 13-amides were shown to exist as two stereoisomers differing by orientation of the amide group plane with respect to the macroring. The reaction of methylpheophorbide a with 2-aminoethanol gave chlorin e 6 derivatives containing one, two, and three hydroxy groups. |
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