Enantioselective C-C bond synthesis catalysed by enzymes |
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Authors: | Sukumaran Joly Hanefeld Ulf |
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Institution: | Gebouw voor Scheikunde, Technische Universiteit Delft, Julianalaan 136, 2628 BL Delft, The Netherlands. |
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Abstract: | The enantioselective synthesis of C-C bonds is often the pivotal step of a synthesis. Nature has made a variety of versatile enzymes available that catalyse this type of reaction very selectively under mild conditions. Cyanohydrins, acyloins (alpha-hydroxy ketones), alpha-hydroxy acids and aldols (beta-hydroxy ketones) are very efficiently synthesised enantioselectively with the aid of C-C bond forming enzymes, which we discuss in this tutorial review. In the case of the alpha-hydroxy acids the applications of nitrilases in a synthetic dkr even allows a disconnection that has no enantioselective chemical equivalent. |
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