Catalytic asymmetric hydroamination of non-activated olefins |
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Authors: | Hultzsch Kai C |
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Affiliation: | Institut für Organische Chemie, Friedrich-Alexander Universit?t Erlangen-Nürnberg, Henkestr. 42, D-91054 Erlangen, Germany. hultzsch@chemie.uni-erlangen.de |
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Abstract: | Hydroamination is a highly atom-economical process in which an amine N-H functionality is added to an unsaturated carbon-carbon linkage. This potentially highly useful process gives access to various nitrogen-containing basic and fine chemicals as well as naturally occurring alkaloid skeletons. Asymmetric hydroamination reactions promoted by chiral catalysts are particularly attractive. This review highlights recent progress in the development of early transition metal catalysts for the asymmetric hydroamination of non-activated alkenes. |
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