Two novel sesquiterpene lactones,cytotoxic vernolide-A and -B,from Vernonia cinerea |
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Authors: | Kuo Yao-Haur Kuo Yu-Jen Yu Ang-Su Wu Ming-Der Ong Chi-Wi Yang Kuo Li-Ming Huang Jo-Ti Chen Chieh-Fu Li Shyh-Yuan |
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Affiliation: | National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, R.O.C. kuoyh@cma23.nricm.edu.tw |
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Abstract: | Bioassay-directed fractionation of an ethanolic extract of stems of Vernonia cinerea has resulted in the isolation of two novel sesquiterpene lactones, vernolide-A and -B. Their structures were elucidated on the basis of spectroscopic analysis. Biological evaluation showed that vernolide-A demonstrated potent cytotoxicity against human KB, DLD-1, NCI-661, and Hela tumor cell lines (ED(50)=0.02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively). |
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