Synthesis of Benzo[4,5]thiazolo[2,3-c][1,2,4]triazole Derivatives via C-H Bond Functionalization of Disulfide Intermediates |
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Authors: | Luis G Ardn-Muoz Jeanne L Bolliger |
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Institution: | Department of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK 74078-3071, USA; |
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Abstract: | Many nitrogen- and sulfur-containing heterocyclic compounds exhibit biological activity. Among these heterocycles are benzo4,5]thiazolo2,3-c]1,2,4]triazoles for which two main synthetic approaches exist. Here we report a new synthetic protocol that allows the preparation of these tricyclic compounds via the oxidation of a mercaptophenyl moiety to its corresponding disulfide. Subsequent C-H bond functionalization is thought to enable an intramolecular ring closure, thus forming the desired benzo4,5]thiazolo2,3-c]1,2,4]triazole. This method combines a high functional group tolerance with short reaction times and good to excellent yields. |
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Keywords: | heteroaromatics C-H bond functionalization oxidative cyclization |
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