Preparation of Thioaminals in Water |
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Authors: | Lídia A S Cavaca Rafael F A Gomes Carlos A M Afonso |
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Institution: | Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; |
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Abstract: | The presence of sulfur–carbon bonds is transversal to several areas of chemistry, e.g., drug discovery, materials, and chemical biology. However, a lack of efficient and sustainable procedures for the preparation of thioaminals, the N,S-analogues of O,O-acetals, contributes to this functional group often being overlooked by the scientific community. In this work is described the formation of thioaminals in water promoted by copper(II) triflate. |
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Keywords: | sustainability aldehyde catalysis |
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