The Highly Efficient Synthesis of 1,2-Disubstituted Benzimidazoles Using Microwave Irradiation |
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| Authors: | Monica Nardi Sonia Bonacci Natividad Herrera Cano Manuela Oliverio Antonio Procopio |
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| Institution: | 1.Dipartimento di Scienze della Salute, Università Magna Græcia, Viale Europa, Germaneto, 88100 Catanzaro, CZ, Italy; (S.B.); (M.O.); (A.P.);2.ICYTAC, Instituto de Ciencia y Tecnología de Alimentos de Córdoba, CONICET, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Bv. Juan Filloy s/n, Córdoba 5000, Argentina; |
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| Abstract: | The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug. Here, we report a simple microwave assisted method for the synthesis of 1,2-disubstituted benzimidazoles. The combination of the molar ratio of N-phenyl-o-phenylenediamine:benzaldehyde (1:1) using microwave irradiation and only 1% mol of Er(OTf)3 provides an efficient and environmental mild access to a diversity of benzimidazoles under solvent-free conditions. The proposed method allows for the obtainment of the desired products in a short time and with very high selectivity. |
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| Keywords: | microwave green chemistry benzimidazoles solvent free conditions Er(OTf)3 |
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