67Cu Production Capabilities: A Mini Review |
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Authors: | Liliana Mou Petra Martini Gaia Pupillo Izabela Cieszykowska Cathy S Cutler Renata Mikoajczak |
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Institution: | 1.Legnaro National Laboratories, National Institute for Nuclear Physics, Legnaro, 35020 Padova, Italy; (L.M.); (G.P.);2.Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy; or ;3.National Centre for Nuclear Research, Radioisotope Centre POLATOM, 05-400 Otwock, Poland;4.Brookhaven National Laboratory, Collider Accelerator Department, Upton, NY 11973, USA; |
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Abstract: | Is the 67Cu production worldwide feasible for expanding preclinical and clinical studies? How can we face the ingrowing demands of this emerging and promising theranostic radionuclide for personalized therapies? This review looks at the different production routes, including the accelerator- and reactor-based ones, providing a comprehensive overview of the actual 67Cu supply, with brief insight into its use in non-clinical and clinical studies. In addition to the most often explored nuclear reactions, this work focuses on the 67Cu separation and purification techniques, as well as the target material recovery procedures that are mandatory for the economic sustainability of the production cycle. The quality aspects, such as radiochemical, chemical, and radionuclidic purity, with particular attention to the coproduction of the counterpart 64Cu, are also taken into account, with detailed comparisons among the different production routes. Future possibilities related to new infrastructures are included in this work, as well as new developments on the radiopharmaceuticals aspects. |
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Keywords: | Cu-67 copper radionuclides production radiopharmaceuticals theranostics |
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