Kinetic resolution of racemic alcohols with chiral carboxylic acids and dicyclohexylcarbodiimide |
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Authors: | Rafael Chinchilla Carmen N jera Miguel Yus Andreas Heumann |
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Affiliation: | Rafael Chinchilla, Carmen Ná,jera and Miguel Yus, Andreas Heumann, |
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Abstract: | The DCC-esterification method has been used to kinetically resolve racemic mixtures of alcohols. With simple chiral carboxylic acids, such as O-aryl lactic acids, in the presence of various basic catalysts, mixtures of the enantiomerically enriched alcohols (e.e. <50%) and the corresponding esters (d.e.<70%) have been obtained. |
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