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Synthetic and conformational aspects of trimethylammonium-methyl substituted 2-oxazolines as potential cholinergics |
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| Authors: | Upinder Fotadar Chris Becu Frans A. M. Borremans Marc J. O. Anteunis |
| Affiliation: | Department of Organic Chemistry, NMR-Spectroscopic Unit, Rijksuniversiteit-Gent, Krijgslaan 271 (S4bis), B-9000 Gent, Belgium |
| Abstract: | The effects of some structural features on the cholinergic activity of 2-oxazoline derivatives has been investigated. Improved synthetic approaches to the 2-oxazoline ring system are developed, and several new fluorinated 2-oxazolines are described. The extensive NMR data give insight into the rotameric behaviour of the substituents. |
| Keywords: | Present address: Department of Medicinal Chemistry School of Pharmacy University of Kansas/Laurence KS 66045 U.S.A.. |
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