Convallasaponin A, a new 5beta-spirostanol triglycoside from the rhizomes of Convallaria majalis |
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Authors: | Higano Taro Kuroda Minpei Sakagami Hiroshi Mimaki Yoshihiro |
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Institution: | Laboratory of Medicinal Pharmacognosy, Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, Hachioji, Tokyo, Japan. |
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Abstract: | The rhizomes of Convallaria majalis have been analyzed for their steroidal glycoside constituents, resulting in the isolation of a new 5beta-spirostanol triglycoside, named convallasaponin A, along with two known cardenolide glycosides and a known cholestane glycoside. The structure of convallasaponin A was determined on the basis of extensive spectroscopic analysis, including 2D NMR data, and the results of hydrolytic cleavage. The cardenolide glycosides showed tumor specific cytotoxic activity. |
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